Prospective collection of biospecimens for Automated Liquid Biopsy test development – a short review of the latest investigations by BIOMEDICA CRO
A novel, Automated Liquid Biopsy test in development by researchers at the Johns Hopkins Kimmel Cancer Center can accurately detect the presence of cancer DNA in the blood of patients with metastatic Breast cancer within five hours.
The test, called the Liquid Biopsy for Breast Cancer Methylation (LBx-BCM), is compatible with a commercially available molecular testing platform called GeneXpert® and can detect methylation, a type of chemical tag, in one or more of nine genes altered in Breast cancers in 4.5 hours.
For this study, scientists used prospective collection of blood from donors with metastatic Breast carcinoma.
They examined cumulative methylation of the 9 genes in 20 serum samples from patients with metastatic Breast cancer and 20 from people without oncology. A second set of samples from 40 people with metastatic Breast cancer, 17 with benign Breast disease and nine without cancer, was analyzed. In both sets, LBx-BCM detected two- to 200-fold more methylated DNA in plasma samples from those with Breast cancer than in normal or benign samples.
“Further prospective clinical trials will evaluate LBx-BCM’s detection sensitivity and its ability to monitor therapeutic response during treatment for advanced Breast cancer,” Sukumar and colleagues wrote.
Please find more information in the AACR journal, research article, “Development of an Automated Liquid Biopsy Assay for Methylated Markers in Advanced Breast Cancer”.
Prospective collection of samples for your research by BIOMEDICA CRO
BIOMEDICA CRO provides both prospective and retrospective collections of the numerous human biospecimen types and associated clinical data since 2017.
Our main area is oncology – Breast, CRC, Ovarian, Prostate, Lung, and Stomach cancer patients can become donors for your research. Besides oncology, we have 50+ contracted clinical sites in a broad range of disease areas.
Due to our business model and direct way of communication with Primary Investigators you will get the highest quality of human biospecimen and insurance that all project details are followed.
For instance, we can provide next types of blood samples:
- Whole blood;
- Serum;
- Buffy coat;
- PBMCs;
- Red sells, etc.
BIOMEDICA CRO operates within the strictest ethical guidelines.
It means that all clinical materials are exclusively obtained after approval of the Institutional Review Board or the Independent Ethical Committee (IRB/IEC) as well as all donors are mandatory consented and signed the Individual Consent Form.
Please email us to start our collaboration: office@biomedica-cro.com / LinkedIn.
